Results
During the study period, there were 1759 drugs registered by the EMA. Among them, 1409 were authorized products. In total, 4215 documents incorporating product information, public assessment report, and scientific discussion documents were extracted from the authorized products. A list of keywords on adaptive designs (Table 2) was used to identify 91 documents of interest after 4 duplicated documents were removed [5, 7-10].
Table 2. Definitions of adaptive designs