Title: Symptomatic Hyperammonemia Secondary to Recombinant Erwinia
Asparaginase
Catherine E. Martin, Pharm.D., Department of Pharmacy – Ambulatory
Service, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Mira A. Kohorst, M.D., Department of Pediatric and Adolescent Medicine,
Division of Pediatric Hematology/Oncology, Mayo Clinic, 200 First Street
SW, Rochester, MN 55905, USA
Asmaa Ferdjallah, M.D., M.P.H, Department of Pediatric and Adolescent
Medicine, Division of Pediatric Hematology/Oncology, Mayo Clinic, 200
First Street SW, Rochester, MN 55905, USA
Jessica L. Kalmes, APRN, C.N.P., M.S.N, Department of Pediatric and
Adolescent Medicine, Division of Pediatric Hematology/Oncology, Mayo
Clinic, 200 First Street SW, Rochester, MN 55905, USA
Heather M. Johnson, APRN, C.N.P., M.S.N, Department of Pediatric and
Adolescent Medicine, Division of Pediatric Hematology/Oncology, Mayo
Clinic, 200 First Street SW, Rochester, MN 55905, USA
Paul J. Galardy, M.D., Department of Pediatric and Adolescent Medicine,
Division of Pediatric Hematology/Oncology, Mayo Clinic, 200 First Street
SW, Rochester, MN 55905, USA
Shakila P. Khan, M.D., Department of Pediatric and Adolescent Medicine,
Division of Pediatric Hematology/Oncology, Mayo Clinic, 200 First Street
SW, Rochester, MN 55905, USA
Alexis K. Kuhn, Pharm.D., Department of Pharmacy – Ambulatory Service,
Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Corresponding author: Catherine E. Martin; address: 200 First Street SW,
Rochester, MN 55905; phone: 507-284-2695; fax: 507-266-4912; email:
martin.catherine3@mayo.edu
Main text word count: 967
Number of tables, figures, and supporting information: None
Short running title: Hyperammonemia after recombinant Erwinia
asparaginase
Keywords: Asparaginase, hyperammonemia, pediatrics, Erwinia, leukemia
Abbreviations