CD40-CD40L and ICOS-ICOSL expression are correlated in nasal polyps of CRS patients
Then, we investigated the correlation of CD40-CD40L and ICOS-ICOSL expression in the nasal tissue of our CRS patients. Our correlation analysis results show that there was a significantly positive correlation between ICOS and CD40 expression (r=0.7875, p<0.0001, Fig. 2A), ICOSL and CD40 expression (r=0.5232, p=0.0061, Fig. 2B), ICOS and CD40L expression (r=0.5604, p=0.0102, Fig. 2D), as well as ICOS and ICOSL expression (r=0.6389, p=0.0018, Fig. 2F). Similar correlation tendencies were observed between CD40L and CD40 expression (Fig. 2C), as well as CD40L and ICOSL expression (Fig. 2E), whereas there was no significant correlation shown.