Conclusions
We successfully established an aging model for the hippocampus and NSCs using D-gal. The mechanism by which ginsenoside Rg1 delays the aging of mouse hippocampus and NSCs is related to the activation of the Keap1-Nrf2/ARE pathway, which increases the expression of related antioxidant enzymes and genes, thereby reducing the level of oxidative stress. Additional research is required to determine how Rg1 protects the hippocampus from damage.