Conclusions
We successfully established an aging model for the hippocampus and NSCs
using D-gal. The mechanism by which ginsenoside Rg1 delays the aging of
mouse hippocampus and NSCs is related to the activation of the
Keap1-Nrf2/ARE pathway, which increases the expression of related
antioxidant enzymes and genes, thereby reducing the level of oxidative
stress. Additional research is required to determine how Rg1 protects
the hippocampus from damage.