Rg1 protected the hippocampus against oxidative stress damage
induced by D-gal
In order to determine whether the aging damage of hippocampus was caused
by oxidative stress, the indexes related to oxidative stress were
determined.The D-gal group SOD(Fig.6 A) and CAT(Fig.6 B) activity
reduced in comparison to the Control group, while their MDA(Fig.6 C),
4-HNE(Fig.6 D), and 8-OHdG(Fig.6 E) concentrations increased. In
comparison to the D-gal group, the D-gal + Rg1 group enhanced its SOD
and CAT activities while decreasing its MDA, 4-HNE, and 8-OHdG
content(paired t test, n=3, p<0.05). In short, oxidative stress damage
can cause aging.