Background
Kimura disease (KD) is a rare, inflammatory, idiopathic condition
characterized by painless, slow-growing subcutaneous masses frequently
in the head and neck region (1, 2), that occurs more commonly in young
males with a peak incidence in their second to fourth decades of life
(3).
Renal involvement is the leading systemic manifestation of KD (2).
Different types of kidney disorders have been reported to be related to
KD, such as membranous glomerulonephritis, mesangial proliferative
glomerulonephritis, minimal change disease, IgA nephropathy, focal
segmental glomerular sclerosis (FSGS), and acute tubular injury (4).
However, the underlying mechanisms of KD and its renal-associated
involvement remain unknown. (5)
KD diagnosis is often challenging and easily misdiagnosed due to its
rarity (6).
So far, different therapeutic approaches, such as surgical excision,
immunosuppressive agents (such as thalidomide and cyclosporine), and
local radiotherapy, are recommended for KD management (7, 8). However,
there is still no specific protocol for definitive KD treatment, and KD
patients experience a high rate of recurrence, up to 62%(9).
Here, we reported a 13-year-old male patient who was hospitalized as a
result of the nephrotic syndrome relapse and was eventually diagnosed as
a case of KD.