HJY, YT, RCJ, DQZ, and XCL contributed substantially to the collection of literature, the study design, the data interpretation. XCL and SJC performed the writing of the manuscript. DQZ and XCL contributed to the acquisition of data. DQZ performed the pharmacokinetics of drugs and methodology of LC-MS/MS. XCL completed the cerebrospinal fluid collection part of experiment and cell culture. DQZ, JYZ, XCL and YZW performed mass spectrometry. RTZ, YFH and YDG provided their suggestions in this study. All authors read and approved the final manuscript.