Pharmacokinetic parameters were estimated from plasma concentration data via non-compartmental analysis using the professional pharmacokinetic software DAS 3.0 (Drug and statistics software 3.0). The experimental data were presented as mean ± SD or median (25^th–75^th percentile), depending on a normal or skewed distribution of data determined by the Shapiro-Wilk test. GraphPad Prism 9.0 was used to perform statistical analyses. Comparisons between the two groups were tested by a two-tailed Student’s t-test or Mann-Whitney U test based on the distribution of data. The difference among multiple groups was evaluated by one-way analysis of variance (one-way ANOVA). Statistical significance was defined as P < 0.05.