| Drug |
Parameter |
ATV |
ATV+DXM |
GMR (90%CI) |
| ATV |
Cmax (ng/mL) |
23.565±9.41 |
27.6±8.605* |
1.388 (0.774-2.003) |
|
AUC(0-t) (ng·h/mL) |
51.785±16.625 |
105.939±37.474* |
2.156 (1.495-2.817) |
|
AUC(0-∞) (ng·h/mL) |
59.007±20.732 |
143.022±55.368* |
2.550 (1.777-3.324) |
|
tmax (h) |
1 (0.58-1) |
0.42 (0.25-3) |
—— |
|
t1/2 (h) |
5.379±2.242 |
16.476±18.848* |
2.304
(1.128-4.707) |
|
o-ATV
|
Cmax (ng/mL) |
36.688±10.381 |
36.478±17.13 |
1.313 (0.475-2.152) |
|
AUC(0-t) (ng·h/mL) |
109.793±40.675 |
242.318±95.706* |
2.320 (1.671-2.969) |
|
AUC(0-∞) (ng·h/mL) |
112.6±41.404 |
257.492±87.942* |
2.420 (1.800-3.004) |
|
tmax (h) |
1.75 (1-3) |
1.25 (0.25-2) |
—— |
|
t1/2 (h) |
2.627±1.01 |
5.73±2.261* |
2.196(1.421-3.394) |
|
p-ATV
|
Cmax (ng/mL) |
4.082±1.807 |
4.062±1.544 |
1.106 (0.706-1.505) |
|
AUC(0-t) (ng·h/mL) |
16.905±7.234 |
36.331±12.913* |
2.209 (2.034-2.384) |
|
AUC(0-∞) (ng·h/mL) |
18.038±7.577 |
45.02±13.478* |
2.676 (1.908-3.443) |
|
tmax (h) |
1.5 (0.58-12) |
1.5 (1-12) |
—— |
|
t1/2 (h) |
4.17±1.821 |
10.349±5.325* |
2.457(1.565-3.857) |