Impact of thrombophilia associated mutations
All women showed thrombophilia associated mutations, except one who did not give consent for this kind of genetic testing. 41 women had a PAI1 mutation, 39 a prothrombin 19911 mutation, 27 a fibrinogen alpha mutation, 19 a fibrinogen gamma mutation, seven a factor V Leiden mutation, six a HR2 mutation, two a prothrombin 20210 mutation, two a FSAP mutation, one a MTHFR mutation, and none had a tPA mutation.
From 16 women with only one mutation 13 gave births (81 %), two had aborts (13 %), and one did not get pregnant (6 %). From 16 women with two mutations 12 gave births (75 %), three had aborts (19 %), and one did not get pregnant (6 %). Three mutations were found with 15 women, of whom seven gave births (47 %), seven had aborts (47 %), and three did not get pregnant (20 %). Four to six mutations were found in 12 women. Of these women, seven gave births (64 %), five had aborts (45 %), and one woman did not get pregnant (9 %) (table 2).
A chi-square test was used to compare number of thrombophilia associated mutations (one or two versus three or more) and successful pregnancies. No expected cell frequencies were below 5. Results showed no significant correlation with χ²(1) = 1·701, p(χ²) = 0·192, p(Fisher’s exact test) = 0·276, V = 0·170.