The present study have used space observations of NO emission (OMI) and aerosol optical depth (AOD) (MODIS) from the last couple of years (2015-2019) to investigate the changes in air pollution in response to COVID-19 pandemic during the lockdown period (Mar-May, 2020) over the Indo-Pak region. Result of this study reveals a huge drop in air pollution that accounted for 40-50% reduction in NO emissions and 45% in AOD over the whole Indo-Pak region. The major metropolitan areas (cities) of the region showed a remarkable decrease in NO emissions, whereas the calculated rate of reduction was found highest for the city of Lahore (Pak) ranges between 29-52% followed by Ahmadabad (Chennai) as 27-52% (32-42%) respectively. The geospatial analysis revealed the existence of positive correlation (range from 0.23-0.50) between AOD and NO emissions, which further implies that a decrease in AOD may be attributed to reduction in NO to some extents.