Author contributions:
T.G., L.G., and J.Y. conceived and designed the project. L.Z., X.H., J.X., H.P., Y.S., Y.C., Z.Z. and X.L. conducted the experiments and analyzed the data. X.H. and L.G. provided the GWAS population and collected the SOC data. X.L. and J.Y. contributed analysis tools and provided suggestions. L.G and T.G. wrote the manuscript. All authors read and approved the final manuscript.