2.1. Animals
Adult male JAX™ C57BL/6J (B6J), C57BL/6NCrl (B6N) and 129S2/SvPasCrl (129) mice were purchased from Charles River Laboratories at the age of eight-weeks old (Erkraht, Germany). Animals were allowed to acclimatize (group-housed; 3 to 5 mice per cage) to our in-house animal facility (inverted light-dark cycle) for at least 5 days before starting the experiments. All experiments were conducted in accordance with the European and German regulations for animal experiments and were approved by the local authorities (42502-2-1295 OvGMD). All experiments were performed during the dark phase.