Figure 1. Enhanced sharp wave-ripples (SW-R) across CA3-CA1 hippocampal axis of B6N and 129 mouse strains. (a) Spontaneous SW-R were recorded from hippocampal CA3 and CA1 pyramidal layers. Representative local field potential recordings from the CA3 (top) and CA1 (down). An individual CA1 SW-R is marked, and low-pass-filtered SW (<45 Hz) and band-pass-filtered ripple (120-300 Hz) components are shown below. (b) Representative local field potential recordings from hippocampal CA3 and CA1 showing an increased SW incidence in CA1 subregion of B6N and 129 strains. Summary graphs (B6J: N=7 mice, n=19 slices; B6N: N=7 mice, n=20 slices; 129, N=7 mice, n=20 slices) illustrating (c) increased CA3 SW incidence in B6N strain and (d) CA1 SW incidence in both B6N and 129 strains. Summary graphs showing (e) reduced propagation failure in 129 in comparison to other strains and (f) enhanced CA3-CA1 correlation during SW-R events in B6N and 129 compared to B6J.(g) Representative SW-R in CA3 and CA1 subregions for each mouse strain. SW-R were low-pass-filtered (<45 Hz) to isolate SW and band-pass-filtered (120-300) to isolate ripples. Summary data for CA3 subregion illustrating a significantly increased (h) SW area in B6N strain, (i) no change in signal-to-noise ratios,(j) enhanced ripple amplitudes in B6N in comparison to 129 and(k) reduced ripple frequencies in B6N in comparison to other strains. Summary data for CA1 subregion illustrating significantly enhanced (l) SW area, (m) signal-to-noise ratios,(n) ripple amplitudes in B6N in comparison to B6J substrain and(o) similar ripple frequencies across investigated strains. Statistical comparison for (c), (e), (f): one-way-ANOVA followed by posthoc comparison using Fisher LSD Method. Statistical comparison for (d), (h), (i), (j), (k), (l), (m), (n), (o):Kruskal-Wallis One Way Analysis of Variance on Ranks followed by posthoc comparison using Dunn´s Method. Post-hoc statistical differences are indicated via *p<0.05, **p<0.01 and ***p<0.001. Data are presented ± standard error of mean (SEM). Empty circles represent individual data points.