Figure 2: Schematic for the role of betaine in the brain. Betaine plays an active role in neuroprotection and against oxidative stress in cells. In neurodegenerative disease as Alzheimer’s, Parkinson’s, and in Schizophrenia, betaine can be a possible therapeutic. Although betaine is actively regulated by BGT-1 in GABAergic pathways, the complete mechanism behind to be determined.