Different ionospheric climatological models such as NeQuick2 and NTCM have been developed to mitigate the ionosphere impact on the trans-ionosphere propagating radio wave. Moreover, the Neural Network (NN) is used to model and characterize the ionosphere. However, no one has compared the performances of NeQuick2, NTCM, and NN after adapting to GPS TEC. This study evaluates their performances in the East-African region in 2013 and 2015. It has been done by computing their drivers (effective ionization level, Az for NeQuick2 and ionization driving index, Id for NTCM) through least-square fitting to TEC observation sense. NN-algorithm has also been trained and tested with observed TEC used for NeQuick2 and NTCM adaptation. The annual performance test has shown that the correlation coefficient (R) values between observed and NTCM modeled TEC, after an adaption, are better than the corresponding values obtained from NeQuick2 and NN. It also shows that the standard deviations (STD) and root-mean-square errors (RMSE) obtained for NTCM are smaller than the STD and RMSE computed for NeQuick2 and NN. On the other hand, the daily performance test of now-casting and predicting showed that the NN performs the best, followed by NTCM. However, the 1-hour prediction test showed that NTCM performs the best among the models considered in this study.