Scrophularia striata leaf aqueous extract green-synthesized silver
nanoparticles: Characterization and cytotoxicity, antioxidant and
anti-nerve cancer effects
Abstract
In the present study, we tried to prepare and formulate a
chemotherapeutic drug (Silver nanoparticles in aqueous medium using
Scrophularia striata leaf extract) for the treatment of nerve cancer.
The chemical characterization tests including UV–Visible Spectroscopy
(UV-Vis), Fourier Transformed Infrared Spectroscopy (FT‐IR), and Field
Emission Scanning Electron Microscopy (FE‐SEM) were used for the
characterization of silver nanoparticles. To survey the cytotoxicity and
anti-nerve cancer effects of AgNO3, S. striata aqueous extract, and
AgNPs, MTT assay was used on the nerve (Human peripheral nerve sheath
tumor (S462 and BL1391)) cancer cell lines. For investigating the
antioxidant properties of AgNO3, S. striata aqueous extract, and AgNPs,
the DPPH test was used in the presence of butylated hydroxytoluene as
the positive control. In the FE-SEM images, the silver nanoparticles
were in an average size of 36.19 nm with the spherical shape. The
results of MTT assay confirmed removing the S462 and BL1391 cell lines
after treating with low concentrations of AgNPs. AgNPs inhibited half of
the DPPH molecules in the concentration of 97 µg/mL. As mentioned, AgNPs
had significant anti-nerve cancer properties against the above cell
lines.