Abbreviation: AKI, acute kidney injury; FENA, fractional excretion of
sodium; E, ethambutol; eGFR, estimated glomerular filtration rate; H,
isoniazid; KDIGO, kidney disease: improving global outcome; R, rifampin;
RBC, red blood cell; TB, tuberculosis; WBC, white blood cell; Z,
pyrazinamide
All received standard four-combined treatment after TB diagnosis.
* Estimated Glomerular Filtration Rate (eGFR) was estimated by
Modification of Diet in Renal Disease (MDRD) formula: [GFR = 175 ×
Serum Cr-1.154 × age-0.203 × 1.212
(if patient is black) × 0.742 (if female)]19
# KDIGO staging criteria:18
Stage 1, Increase in serum creatinine of ≥26.53 μmol/L or 1.5 to 1.9
times baseline OR Urine output of <0.5 mL/kg/hour for 6 to 12
hours
Stage 2, Increase in serum creatinine to 2.0 to 2.9 times baseline OR
Urine output of <0.5 mL/kg/hour for 12 to 24 hours
Stage 3, Increase in serum creatinine to ≥3.0 times baseline OR Increase
in serum creatinine of ≥26.53 μmol/L to ≥353.68 μmol/L OR Urine output
of <0.3 mL/kg/hour for ≥24 hours or anuria for ≥12 hours OR
Initiation of kidney replacement therap
Table 4. Predictors for acute kidney injury (AKI), by
multivariate cox proportional hazards regression analysis