Evaluation of burden of gynecological malignancies
The incidence and mortality of gynecological malignancies in the GBD dataset were evaluated in the following ways: (1) based on all the data sources that reported incidence and mortality of cervical cancer, uterine cancer and ovarian cancer (with international disease classification codes), the mortality-to-incidence ratio (MIR) was computed; (2) we calculated mortality estimates by multiplying cancer register incidence data by the MIR; (3) all these data were used as input to follow the Cause of Death Ensemble model process to determine the cancer-specific mortality of cervical cancer, uterine cancer and ovarian cancer; and (4) we divided the cancer-specific mortality of cervical cancer, uterine cancer and ovarian cancer estimates by the MIR to generate incidence. DALYs were computed by adding years of life lost (YLLs) and years lived with disability (YLDs).