Revana Siddappa BC,
Department of Pharmaceutical chemistry NGSM Institute of Pharmaceutical
Sciences (NGSMIPS) Nitte (Deemed to be university) Mangalore, Karnataka,
India.
E-mail: revan@nitte.edu.in
Abstract: In terms of human mortality, cardiac diseases have a
higher mortality rate than cancer. Along with mortality rates, cancer
morbidity also paints a rather miserable picture. Management of cancer
continues to be a difficult task despite advancements in treatment
modalities. Cytotoxicity is one of the key indicators for in vitro
biological evaluations. Cytotoxic drugs have been shown to disrupt cell
membranes, inhibit protein synthesis, and bind receptors irreversibly. A
number of short-term cytotoxic effects and cell proliferation assays
have been created and used to identify cell death brought on by these
results. Among the in vivo models that have been developed are those
that mimic chemical carcinogenesis and xenografts for human
malignancies. The current in-vitro and animal models used in the
development and evaluation of the therapeutic efficacy of anti-cancer
drugs are covered in this article.
Key words: - Anticancer, cancer, cell viability, cytotoxicity,in vitro , in vivo