2.3.1 UV induced skin tumorigenesis in SKH-1 hairless mouse
Over a total dose of 74.85 J/cm2 UV-A and 2.44
J/cm2 UV-B in the 22 weeks, the hairless Inbred
(SKH-1) mouse if exposed to UVA and UVB by week 23, radiated mouse
acquires on average 16 mouse tumours, with an average of 2.1 mouse
carcinomas. The incidence of skin tumours, tumour multiplicity, the
decrease of skin papillomas, the onset of early tumour appearance,
histological examination of the tumour, and the expression of
tumor-related proteins involved in cell cycle regulation are all
investigated(Hong et al., 2001).