Discussion
Pneumonia patients are a common disease among hospitalized patients. In the context of the COVID-19 pandemic, our study is the first to analyze changes in virus detection in patients with pneumonia post-COVID-19. We found that the detection of post-COVID-19 virus and influenza virus had decreased 23.3% and 18.3%,respectively,Although the virus testing rate is gradually increasing.And the need for invasive ventilation support in post-COVID-19 patients had increased.This has implications for the prevention of influenza virus post-COVID-19 and the selection of appropriate treatment.
We have the following conclusions that the detection of influenza viruses decreased post-COVID-19, especially InfAH1N1(2009),Influenza virus accounted for an important part of virus detection before COVID-19 occurred.In apopulation-based study[4] of community-acquired pneumonia in 2017, The viruses are dominated by rhinovirus,influenza virus . And from January to July 2016, West China Hospital conducted viral nucleic acid testing for outpatient and inpatient patients of all age groups, indicating that the highest detection rate of a single viral nucleic acid detection was rhinovirus and alpha-fluid H1N1 2009.The possible reasons for this result are similar to the previous epidemics of other influenza viruse,the virus transmission law of China (H1N1) influenza pandemic in 2009 and the SIRD virus transmission model of prevention and control strategy show that school suspension, the factory stopped production,restricting free flow of population, expanding the scope of suspected cases,vaccination and other are effective measures to control the outbreak.In China, regional and local governments, including Hubei, have strengthened the prevention measures since January 2020 to curb the spread of COVID-19[5]. Many cities in Hubei province have been locked down, and many measures have been implemented, such as tracking close contacts, isolating infected people, and promoting social consensus on self-protection (such as wearing masks[6] in public places, minimum social distancing), so the effect of the full implementation of preventive measures is also obvious.
In our study, the positive microbiological result was low, from 34.4% pre-COVID-19, but only 24% post-COVID-19,This is similar to HAESSLER S’s study[7] ;and the microbe delivery rate decreased, probably because there are more options for other pathogen testing methods.
There are limitations regarding this study.First, this study is a single-center descriptive study, a center can only represent the epidemic of the region at that time, can not represent the whole of China or can be extended to other environments, because the transmission of respiratory pathogens according to different geographical area, time and other factors, when conditions allow, we expect to complete the national multi-center study.Secondly, all the data came from the retrospective case data, but we went through the rigorous screening of the data to ensure the data rigor.Second, Our study into the detection of the virus for positive method for 13 viral nucleic acid testing programs, which other hospitals may not have, and the study detection method is conducted in our hospital in recent years, so in our table 1, after the new crown the inspection rate is increased, so we obtained the virus detection positive rate of the total data early some years of data may be lower. However, according to some literature, the results on the etiology of pre-COVID-19 are basically consistent with some studies.Third, the missing vaccine information that the patient had had had an impact on the baseline information, so we cannot rule out a viral infection after the patient had been vaccinated.In conclusion, this study shows that we should deinject the vaccine according to the prevalence of the etiology at each stage of the CAP, reducing the waste of medical resources.
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