CONCLUSION
In summary, HHV8 and EBV-negative PEL is an extremely rare neoplasm involving body cavities without detectable tumor mass, characterized by atypical blastic cells expressing pan-B-cell markers. Unlike PEL, HHV8 and EBV-negative PEL usually presents in elderly patients without known immunodeficiency. Distinguishing PEL-like from PEL is important because better response to treatment and outcomes are achieved with standard therapies. Further investigation is needed to better understand this entity. To our knowledge, few cases of this new recognized entity have been described in Caucasians.