CONCLUSION
In summary, HHV8 and EBV-negative PEL is an extremely rare neoplasm
involving body cavities without detectable tumor mass, characterized by
atypical blastic cells expressing pan-B-cell markers. Unlike PEL, HHV8
and EBV-negative PEL usually presents in elderly patients without known
immunodeficiency. Distinguishing PEL-like from PEL is important because
better response to treatment and outcomes are achieved with standard
therapies. Further investigation is needed to better understand this
entity. To our knowledge, few cases of this new recognized entity have
been described in Caucasians.