Introduction
The detection and assessment of areas of leakage in fluorescence
angiography (FA) images are crucial for both the diagnosis and
management of different choroidal and retinal diseases. Leaking
fluorescein may result from attenuated blood vessels such as retinal
neovascularization (NVE), choroidal neovascularization (CNV), or through
a weakened retinal pigment epithelium (RPE) that no longer prevents
leakage of fluorescein from the choroid. (1) FFA leakage is
characterized by early hyperfluorescence, increasing with time in both
area and intensity, and blurring of the vessel’s margins. (1) It occurs
as a result of two main mechanisms: dysfunction of existing vascular
endothelial tight junctions as seen in diabetic retinopathy (DR),
cystoid macular edema (CME), branch and central retinal vein occlusion
or due to the primary absence of vascular endothelial tight junctions
which seen in CNVs, some vascular disorders like Coats disease, or
Behcet׳s disease. (2,3) We reported fluorescence leakage secondary to
rhegmatogenous retinal detachment (RD) in a seven-year-old child and
explained how this association made confusion to reach the
diagnosis.