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Comparative genomic analysis and constraint-based analysis of genome-scale metabolic models of the genus Clostridia
  • Karan Kumar,
  • Lepakshi Barbora,
  • Vijayanand S. Moholkar
Karan Kumar
Indian Institute of Technology Guwahati
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Lepakshi Barbora
Indian Institute of Technology Guwahati
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Vijayanand S. Moholkar
Indian Institute of Technology Guwahati

Corresponding Author:[email protected]

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In recent years, bacteria from genus Clostridia have attracted attention of research community because of their biofuel production capabilities. Present study reports comparative genomic (CG) analysis of 48 genomes of solventogenic and saccharolytic Clostridia. We have focused on central carbon metabolism and general stress response in the analysis. Comprehensive summaries on comparison of general genome features, COG categories, CDSs of the energy, catabolic, and sporulation pathways are given. Furthermore, we have proposed two new genome-scale metabolic (GSM) models iKK848 and iKK1425 for Clostridium pasteurianum DSM 525 = ATCC 6013 and Clostridium acetobutylicum ATCC 824, respectively. These GSM models are most comprehensive in that they account for the largest number of reactions, metabolites, and genes as compared to previous models. Model quality and metabolic flux optimization for biomass growth using iKK1425 and iKK848 are compared with previous literature. Our models had the highest quality score of 61% and 77%.
15 Nov 2022Submitted to Biotechnology and Bioengineering
16 Nov 2022Submission Checks Completed
16 Nov 2022Assigned to Editor
16 Nov 2022Review(s) Completed, Editorial Evaluation Pending
21 Dec 2022Reviewer(s) Assigned
22 Mar 2023Editorial Decision: Revise Major
02 Jun 20231st Revision Received
02 Jun 2023Assigned to Editor
02 Jun 2023Submission Checks Completed
02 Jun 2023Review(s) Completed, Editorial Evaluation Pending
29 Jun 2023Reviewer(s) Assigned
11 Aug 2023Editorial Decision: Revise Major
28 Sep 20232nd Revision Received
29 Sep 2023Submission Checks Completed
29 Sep 2023Assigned to Editor
29 Sep 2023Review(s) Completed, Editorial Evaluation Pending
29 Sep 2023Reviewer(s) Assigned
14 Oct 2023Editorial Decision: Revise Minor
20 Oct 20233rd Revision Received
20 Oct 2023Assigned to Editor
20 Oct 2023Submission Checks Completed
20 Oct 2023Review(s) Completed, Editorial Evaluation Pending
16 Nov 2023Editorial Decision: Accept