Normothermic perfusion of
cirrhotic and non-cirrhotic explanted human livers: applicability to
study drug pharmacokinetics
Lianne J. Stevens1,2,3, Jeroen
Dubbeld1,2, Jason B. Doppenberg2,
Bart van Hoek2,4, Aswin L. Menke3,
Joanne M. Donkers3, Abdulnaser
Alsharaa3, Arjan de Vries3, Wouter
H.J. Vaes3, Catherijne A.J. Knibbe5, Evita van de Steeg3 and Ian P.J.
Alwayn1,2
1 Department of Surgery, Leiden University Medical
Center (LUMC), Leiden, the Netherlands
2 LUMC Transplant Center, Leiden University Medical
Center (LUMC), Leiden, the Netherlands
3 The Netherlands Organization for Applied Scientific
Research (TNO), Zeist, the Netherlands
4 Department of Gastroenterology and Hepatology,
Leiden University Medical Center (LUMC), Leiden, the Netherlands
5 Division of Systems Biomedicine and Pharmacology,
Leiden Academic Center for Drug Research (LACDR), Leiden University,
Leiden & Department of Clinical Pharmacy, St. Antonius Hospital
Nieuwegein & Utrecht, the Netherlands
Data availability: All data generated or analysed during this
study are included in this published article and its supplementary
information files
Funding statement: This work received no external funding