Normothermic perfusion of cirrhotic and non-cirrhotic explanted human livers: applicability to study drug pharmacokinetics
Lianne J. Stevens1,2,3, Jeroen Dubbeld1,2, Jason B. Doppenberg2, Bart van Hoek2,4, Aswin L. Menke3, Joanne M. Donkers3, Abdulnaser Alsharaa3, Arjan de Vries3, Wouter H.J. Vaes3, Catherijne A.J. Knibbe5, Evita van de Steeg3 and Ian P.J. Alwayn1,2
1 Department of Surgery, Leiden University Medical Center (LUMC), Leiden, the Netherlands
2 LUMC Transplant Center, Leiden University Medical Center (LUMC), Leiden, the Netherlands
3 The Netherlands Organization for Applied Scientific Research (TNO), Zeist, the Netherlands
4 Department of Gastroenterology and Hepatology, Leiden University Medical Center (LUMC), Leiden, the Netherlands
5 Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research (LACDR), Leiden University, Leiden & Department of Clinical Pharmacy, St. Antonius Hospital Nieuwegein & Utrecht, the Netherlands
Data availability: All data generated or analysed during this study are included in this published article and its supplementary information files
Funding statement: This work received no external funding