Perfusate Perfusate Perfusate Bile Bile Bile
Cirrhosis Non-cirrhosis p Cirrhosis Non-cirrhosis p
Rosuvastatin Cmax (µg/mL) 0.46 (0.24-0.55) 0.04 (0.01-0.07) 0.024 10.23 (0.44-16.82) 9.45 (5.62-13.25) 0.762
AUC0-tau 20.96 (11.61-29.98) 0.11 (0.10-5.15) <0.001 1194.10 (762.41-1833.30) 848.01 (696.68-904.79) 0.114
Biliary excretion (% of dose) - - - 66.34 (42.33-101.85) 47.11 (38.70-50.27) 0.114
Digoxin Cmax (ng/mL) 10.03 (7.75-11.78) 3.46 (2.33-7.80) 0.038 671.11 (486.60-982.52) 310.76 (157.90-700.00) 0.353
AUC0-tau 629.70 (282.30-746.10) 222.80 (171.00-503.40) 0.003 62268 (36350-105919) 20423 (8175-109472) 0.352
Biliary excretion (% of dose) - - - 51.89 (30.29-88.26) 17.02 (6.81-91.23) 0.352
Metformin Cmax (ug/mL) 25.79 (21.79-33.75) 22.84 (21.29-27.58) 0.352 12.63 (10.46-17.61) 14.46 (11.15-19.39) 0.762
AUC0-tau 2248.00 (1648.00-2807.00) 1896 (1780.00-2061.00) 0.187 2235.26 (1248.87-2646.74) 1854.08 (1063.47-2904.86) 0.914
Biliary excretion (% of dose) - - - 3.02 (1.69-3.58) 2.51 (1.44-3.93) 0.914
Furosemide Cmax (µg/mL) 0.27 (0.15-0.42) 0.23 (0.18-0.27) 0.476 0.16 (0.05-0.30) 0.03 (0.01-0.32) 0.171
AUC0-tau 18.61 (11.65-28.62) 14.32 (10.37-18.64) 0.073 17.53 (5.99-38.50) 8.22 (1.33-20.88) 0.257
Biliary excretion (% of dose) - - - 2.27 (0.78-5.00) 1.07 (0.17-2.71) 0.257