|
|
Cirrhosis |
Non-cirrhosis |
p |
Cirrhosis |
Non-cirrhosis |
p |
Rosuvastatin |
Cmax (µg/mL) |
0.46 (0.24-0.55) |
0.04
(0.01-0.07) |
0.024 |
10.23 (0.44-16.82) |
9.45 (5.62-13.25) |
0.762 |
|
AUC0-tau
|
20.96 (11.61-29.98) |
0.11 (0.10-5.15) |
<0.001 |
1194.10 (762.41-1833.30) |
848.01 (696.68-904.79) |
0.114 |
|
Biliary excretion (% of dose) |
- |
- |
- |
66.34 (42.33-101.85) |
47.11 (38.70-50.27) |
0.114 |
Digoxin |
Cmax (ng/mL) |
10.03 (7.75-11.78) |
3.46 (2.33-7.80) |
0.038 |
671.11 (486.60-982.52) |
310.76 (157.90-700.00) |
0.353 |
|
AUC0-tau
|
629.70 (282.30-746.10) |
222.80
(171.00-503.40) |
0.003 |
62268 (36350-105919) |
20423 (8175-109472) |
0.352 |
|
Biliary excretion (% of dose) |
- |
- |
- |
51.89 (30.29-88.26) |
17.02 (6.81-91.23) |
0.352 |
Metformin |
Cmax (ug/mL) |
25.79 (21.79-33.75) |
22.84
(21.29-27.58) |
0.352 |
12.63 (10.46-17.61) |
14.46 (11.15-19.39) |
0.762 |
|
AUC0-tau
|
2248.00 (1648.00-2807.00) |
1896
(1780.00-2061.00) |
0.187 |
2235.26 (1248.87-2646.74) |
1854.08
(1063.47-2904.86) |
0.914 |
|
Biliary excretion (% of dose) |
- |
- |
- |
3.02 (1.69-3.58) |
2.51
(1.44-3.93) |
0.914 |
Furosemide |
Cmax (µg/mL) |
0.27 (0.15-0.42) |
0.23 (0.18-0.27) |
0.476 |
0.16 (0.05-0.30) |
0.03 (0.01-0.32) |
0.171 |
|
AUC0-tau
|
18.61 (11.65-28.62) |
14.32 (10.37-18.64) |
0.073 |
17.53 (5.99-38.50) |
8.22 (1.33-20.88) |
0.257 |
|
Biliary excretion (% of dose) |
- |
- |
- |
2.27 (0.78-5.00) |
1.07
(0.17-2.71) |
0.257 |