Figure
1. Molecular consequences of Cys357Arg variant of complement factor H
gene, CFH . Cartoon rendering of a portion of the complement
factor H protein structure, extending from amino acid Tyr321 to Ile443,
derived from PDB file mmdb_4AYE (). A ) Location of the
disulfide bond between Cys357 and Cys385. B) The Cys357Arg mutation
breaks the disulfide bond, potentially destabilizing the molecular
structure. Figure generated and mutagenesis performed with PyMOL
v2.3.36.
Figure 2. Creatinine, platelet, and CH50 trends in a 13-month-old male
diagnosed with metastatic neuroblastoma with diagnosis of aHUS following
first cycle of chemotherapy with topotecan and cyclophosphamide
demonstrating improvement following initiation of therapy with
eculizumab.