Figure 1. Molecular consequences of Cys357Arg variant of complement factor H gene, CFH . Cartoon rendering of a portion of the complement factor H protein structure, extending from amino acid Tyr321 to Ile443, derived from PDB file mmdb_4AYE (). A ) Location of the disulfide bond between Cys357 and Cys385. B) The Cys357Arg mutation breaks the disulfide bond, potentially destabilizing the molecular structure. Figure generated and mutagenesis performed with PyMOL v2.3.36.
Figure 2. Creatinine, platelet, and CH50 trends in a 13-month-old male diagnosed with metastatic neuroblastoma with diagnosis of aHUS following first cycle of chemotherapy with topotecan and cyclophosphamide demonstrating improvement following initiation of therapy with eculizumab.