Conclusion
In this work, we studied aggressive behavior in a rat male model. We concluded that a single and acute pCPA administration produces an increase in aggressive behavior, without affecting locomotion, nonsocial and social activity. We study the OB, a highly innervated serotonergic and GABAergic structure. The pCPA single and acute administration affects the serotonergic activity in OB. We verify TPH2 mRNA expression presence in OB. Moreover, increased GABAAα1 subunit expression mRNA in the OB, may suggest a high synthesis demand, as an alterat result in the OB serotonergic function. Thus, our data provide evidence for the serotonergic deficiency hypothesis of aggression and show OB as a relevant structure to understand neurobiological complexity in aggressive behavior.