Conclusion
In this work, we studied aggressive behavior in a rat male model. We
concluded that a single and acute pCPA administration produces an
increase in aggressive behavior, without affecting locomotion, nonsocial
and social activity. We study the OB, a highly innervated serotonergic
and GABAergic structure. The pCPA single and acute administration
affects the serotonergic activity in OB. We verify TPH2 mRNA expression
presence in OB. Moreover, increased GABAAα1 subunit expression mRNA in
the OB, may suggest a high synthesis demand, as an alterat result in the
OB serotonergic function. Thus, our data provide evidence for the
serotonergic deficiency hypothesis of aggression and show OB as a
relevant structure to understand neurobiological complexity in
aggressive behavior.