Scope of Review: Auditory and Visual, Sensory andWorking Memory
Perturbed bottom-up functioning impairs upstream cognition (Javitt,
2009; Javitt & Sweet, 2015). If sensory encoding is impaired
then the information derived from the impoverished signal will produce
further problems. An immediate consequence of impaired SM is reduced
information available for WM. In addition, WM deficits in schizophrenia
could negatively impact SM too: If WM is inefficient, then manipulating
incoming sensory information will also be impaired. Improvements
anywhere along this loop could have cascading consequences (Figure 1). A
first step is to characterize the relationships between SM and WM
biomarkers and how they are impacted along SSD.