Conclusions
Prophylactic antibiotics in patients with acute stroke did not reduce
the mortality rate and pneumonia but could reduce the incidence of
infections and urinary tract infections. No increase in the risk of
adverse events was observed. Whether to use antibiotics prophylactically
in patients with acute stroke should be balanced their benefits and
risks. Further studies should consider the effect of timing and duration
of prophylactic antibiotics on clinical outcomes to identify patients
who get benefits from prophylactic antibiotics therapy after stroke.
Author Contributions:Conceptualization,
W.Q., Z.S.D. and Y.Z.M.; methodology, W.Q.; software, W.Q.; validation,
W.Q., W.Z.Y. and Y.Z.M.; formal analysis, W.Q. and W.Z.Y.; resources,
W.Q. and Y.Z.M.; data curation, W.Q., W.Z.Y. and Y.Z.M.;
writing—original draft preparation, W.Q.; writing—review and
editing, Z.S.D., W.Z.Y., Y.Z.M. and T.H.L.; supervision, Z.S.D., W.Z.Y.,
Y.Z.M. and T.H.L.; project administration, Z.S.D. and Y.Z.M. All authors
have read and agreed to the published version of the manuscript.
Supplementary Data: Table S1: PRISMA checklist, Table S2:
Search strategies through electronic databases, Figure S1: Forest plot
for the proportion of patients with mRS ≤ 2, Figure S2: Forest plot for
NIHSS score, Figure S3: Sensitivity analyses of mortality rate at
different administration time, Figure S4: Sensitivity analyses of the
proportion of patients with mRS ≤ 2.
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Table 1. Characteristics of the included studies.