RESULTS
Table 1, 2, figure 1 and 2 show the demographic, laboratory characteristics and mutation distribution of patients with BTM and the control group. According to the comparisons, a statistically significant difference was found between the two groups in terms of ADMA averages. Accordingly, the mean ADMA in the BTM group is higher than in the control group. When the groups were compared in terms of laboratory measurements and metabolic properties, proBNP, hemoglobin (hgb), hematocrit (htc), mean corpuscular volume (MCV), red blood cell (RBC), reticulocyte, ferritin and iron measurements were found to be different between the groups. While hgb, htc, MCV and RBC were lower in the BTM, other measurements were higher than in the control group.
ADMA and laboratory measurements were examined in the patient group, there was no correlation between ADMA and other parameters (Table 3, 4).
Endocan and laboratory measurements were analyzed in the patient group, there was no correlation between endocan and other parameters (Table 4, figure 3).
When the echocardiological measurements of the groups were compared, differences were found between the groups in LVISD, LVIDs (left ventricular end-diastole), LVPWd (left ventricular posterior wall), LPWs (left posterior wall), ejection fraction (EF), mitral E, A mitral, S mitral, S septal, Tricuspid A and TR measurements. LVPWd, LPWs, EF and S mitral measurements were lower in beta-thalassemia group, while other measurements were higher (Table 5, figure 3).
Among the groups, ADMA and endocan and echocardiography parameters were studied within the groups, only a weak negative correlation was found between ADMA and tricuspid A. Tricuspid A decreases as the serum level of ADMA increases (Table 5, figure 4).