Study design and patient population
This prospective, single-centre, observational study consecutively enrolled 451 patients with indication for TLE, according with 2018 EHRA expert consensus statement (5). Patients were admitted from spoke centres to our TLE hub centre, from January 2005 to January 2021. Exclusion criteria were: age < 18 years, pregnancy, life expectancy <6 months.
The enrolment started at the time of TLE. All the population was followed-up for early (before discharge) and long-term (after discharge) mortality. Institutional Ethics Committee approval (prot. 202/18, study ID 1846) was taken and a written informed consent was obtained from each participant.