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\begin{document}

\title{Two Cases of Refractory Pediatric Antiphospholipid Syndrome}



\author[1]{Sarah Blain}%
\author[2]{Maria Kondyli}%
\author[2]{Jean-Jacques De Bruycker}%
\author[3]{Rochelle Winikoff}%
\affil[1]{University of Ottawa Faculty of Medicine}%
\affil[2]{CHU Sainte-Justine}%
\affil[3]{Université de Montréal Faculté de Médecine}%


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  \date{June 14, 2024}


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\begin{abstract}
APS is an autoimmune disease in which patients are at increased risk of
thrombosis and/or pregnancy complications. CAPS is a form of severe APS
with multisystemic involvement and microvascular thrombi. Both entities
are treated with anticoagulation and multimodal immunotherapy regimens.
We present two APS cases in which patients did not meet criteria for
CAPS, but needed CAPS-like treatment to stop the progression of
thromboses. This case series stresses the importance of stringent
follow-up in APS to ensure regression of thromboses. They also emphasize
the need of aggressive immunotherapy in refractory APS.%
\end{abstract}%



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\textbf{Hosted file}

\verb`casereport_SB_RW 19mai21.docx`  available at \url{https://authorea.com/users/512874/articles/710220-two-cases-of-refractory-pediatric-antiphospholipid-syndrome}

\textbf{Hosted file}

\verb`Table 1_PBC_SarahBlain.docx`  available at \url{https://authorea.com/users/512874/articles/710220-two-cases-of-refractory-pediatric-antiphospholipid-syndrome}

\textbf{Hosted file}

\verb`Table 2_PBC_SarahBlain.docx`  available at \url{https://authorea.com/users/512874/articles/710220-two-cases-of-refractory-pediatric-antiphospholipid-syndrome}

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