Introduction:
COVID-19 was considered a devastating worldwide pandemic after it caused
the deaths of millions of people worldwide(1). Many
types of research have studied the effects of COVID-19 on physical and
mental health during pregnancy(2–4). Compared to
nonpregnant women of the same reproductive age, pregnant women are at
higher risk of severe illness and mortality from COVID-19, besides also
being at increased risk of unfavorable pregnancy outcomes such as
preterm birth(5–7). At the onset of vaccination
during this pandemic, there was a paucity of safety data on COVID-19
immunization in pregnant women. However, later, the available evidence
documented no harmful maternal or neonatal consequences of the
administration of COVID-19 vaccines to pregnant women, and there is also
a growing body of evidence that supports the safety of such
vaccination(8–12). Findings from three safety
monitoring systems revealed no safety concerns for pregnant women who
received an mRNA COVID-19 vaccine in their late pregnancy, or for
newborns(13). The acceptance among pregnant women
varies, even with the increasing evidence. However, the immunization
rate is still low among pregnant women(14). Pfizer and
Moderna vaccines are the preferred vaccines for eligible pregnant women
of any age because of their more extensive experience of their use in
pregnancy(15). Therefore, this study was conducted to
investigate the effect of different COVID-19 vaccines approved in saudia
arabia on perinatal outcomes.