Conclusion
In conclusion, twin pregnancy was
found to be a significant risk factor for maternal renal dysfunction
(serum creatinine > 0.8 mg/dL).
The rate of maternal renal
dysfunction was not significantly different between dichorionic and
monochorionic twins. In 13 twin pregnancies with renal dysfunction, the
renal function of all women normalized after delivery, without medical
intervention. This suggests that pregnancy induces maternal renal
dysfunction, which is more pronounced in twins. Careful attention should
be paid to maternal renal dysfunction in the management of twin
pregnancies.
Acknowledgements: We thank Editage (https://www.editage.com/)
for the English language editing. We would like to thank Yoshiro Fujita,
a nephrologist, for his valuable comments and advice regarding renal
function. We would like to thank Atsushi Kubo for supporting the data
collection from medical records.
Disclosure of Interests: The authors declare no conflicts of
interest in association with the present study.
Contribution to Authorship: AM was the principal author who
participated in the conceptualization, design, data collection and
management, and data analysis. HT was the corresponding author,
contributed to the design, data collection and management, and data
analysis, and drafted the manuscript. YM, TN, MS, NF, YI, AT, TA, and KM
contributed to the data collection and management. All authors have read
and approved the final manuscript.
Details of Ethics Approval: This study was approved by the
Ethics Committee of the Japanese Red Cross Aichi Medical Center Nagoya
Daiichi Hospital, Nagoya, Japan (approval date: November 9, 2021;
approval number: 2021-422). Informed consent was not required for this
study since we used anonymous clinical data.
Data Availability Statement: The data (de-identified
participant data) that support the findings of this study are available
from the corresponding author (HT) upon reasonable request.