3.4 Late urinary markers of cisplatin-induced acute kidney injury
Aminoisobutanoate (↓4.69-fold), betaine (↓2.67-fold), glutamine (↓1.98-fold), glycolate (↓2.71-fold), histidine (↓2.63-fold), indole-3-acetate (↓4.03-fold), serine (↓2.80-fold), taurine (↓2.56-fold), threonine (↓2.90), and tyramine (↓2.87-fold) were all significantly lower at the post timepoint in the AKI group relative to the no AKI group (Table 2 , Figure 4 ). With the exception of aminoisobutanoate, all of the aforementioned metabolites exhibited AUROC ≥ 0.8 at the post timepoint, with AUROC of glycolate and tyramine being greater than 0.9 (Figure 4H). Though not statistically significant, betaine, indole-3-acetate, and threonine trended lower in AKI patients compared to no AKI patients at the pre timepoint with AUROC values ≥ 0.7 (Figure 4B, 4F, 4I ). Similarly, urine levels of aminoisobutanoate, indole-3-acetate, and tyramine trended lower in AKI patients at the 24-48h timepoint with AUROC ≥ 0.7, though the difference was not statistically significant (Figure 4A, 4F, 4J ).