Abstract
Neonatal lupus erythematosus (NLE) is an unusual and acquired immune-mediated disease. Although cases of NLE among siblings have been reported, they all have the same or similar manifestations. We first report 2 cases of presentation of cutaneous NLE to occur in two siblings with significantly different cutaneous manifestations. The two-child policy led to more families having a second child, so the incidence rate of NLE in siblings may increase too.