1 | INTRODUCTION
Neonatal lupus erythematosus (NLE) is a rare syndrome characterized essentially by cutaneous lesions and/or congenital heart block occurring in infants at birth, or shortly after. It is related to transplacental crossing of maternal auto antibodies (usually anti Ro/SS-A, La/SS-B or rarely anti-U(1) RNP) from the mother to the infant. Mothers of affected children have signs of Sjögren’s syndrome or other collagenosis or are asymptomatic.