1 | INTRODUCTION
Neonatal lupus erythematosus (NLE) is a rare syndrome characterized
essentially by cutaneous lesions and/or congenital heart block occurring
in infants at birth, or shortly after. It is related to transplacental
crossing of maternal auto antibodies (usually anti Ro/SS-A, La/SS-B or
rarely anti-U(1) RNP) from the mother to the infant. Mothers of affected
children have signs of Sjögren’s syndrome or other collagenosis or are
asymptomatic.