Catheter ablation and the incidence of the primary endpoint
Totally, the primary endpoint occurred in 22 (16.8%) patients during the follow-up period, among whom 1 (4.5%) died due to cardiogenic shock, 4 (18.1%) had TE events and 19 (86.4%) had HF hospitalization. Figure 3 shows the Kaplan-Meier curves for the cumulative incidence of primary endpoint (log rank p = 0.018), all-cause death (log rank p = 0.250), TE events (log rank p = 0.220), and HF hospitalization (log rank p = 0.097). The Kaplan-Meier curves for the primary endpoint with PSM and IPTW are shown in Figure S1 and S2, respectively.
As shown in Table 2, the unadjusted HR for the primary endpoint of catheter ablation group versus medical treatment group derived by Cox regression model was 0.353 (95% CI 0.144 – 0.867, p = 0.023). After adjusting for covariates including age, stroke history, eGFR and LVEDD, the HR for catheter ablation was 0.281 (95% CI 0.110 – 0.721, p = 0.008). The incidence of the primary endpoint remained lower in catheter ablation group after PSM and IPTW, with the HR of 0.297 (95% CI 0.116 – 0.756, p = 0.011) and 0.315 (95% CI 0.110 – 0.906, p = 0.032), respectively. Table 3 summarized the HR for the primary endpoint of catheter ablation in various models.