Major findings
This study demonstrated the following key findings.
Firstly, catheter ablation was
significantly associated with a lower incidence of the composite
endpoint of all-cause death, TE events and HF hospitalization in AF and
concomitant HFpEF. Secondly, remarkable reduction in AF recurrence was
observed with contact force-guided ablation compared with medical
treatment. Thirdly, catheter ablation was an independent predictor of
improved HF symptoms and reverse atrial remodeling. To the best of our
knowledge, this is the first study making a direct comparison of the
long-term impact of RFCA to medical treatment on clinical and functional
outcomes in patients with HFpEF and AF.