Patients’ basic information
From January 2014 to December 2021, 1431 children underwent pLT at the
Department of Pediatric Transplantation, Tianjin First Central Hospital.
A total of 76 patients were diagnosed with PTLD by lymph node biopsy,
for an incidence rate of 5.31%. A total of 83 patients were
<14 years old at the time of pLT and underwent lymph node
biopsy and 18F-FDG PET/CT in the same period.
According to the results of lymph node biopsy, 19 patients (22.9%) were
PTLD-negative cases, 47 patients (56.7%) were diagnosed with
non-destructive PTLD, 5 patients (6.0%) were diagnosed with polymorphic
PTLD, 11 patients (13.3%) were diagnosed with monomorphic PTLD, and 1
patient (1.2%) was diagnosed with classical Hodgkin’s lymphoma PTLD
(FIGURE 1 ). See TABLE 1 for the patient
characteristics. There were 44 boys (53%) and 39 girls (47%), with a
median age of 7.27 (range, 5.85–8.70) months. Among these patients, 73
(88%) underwent pLT for biliary atresia and 10 (12%) underwent pLT for
other reasons. Sixty-four patients (77.1%) received LDLT and 19
patients (22.9%) received DDLT. The EBV result was positive in 60 cases
(72.3%) and negative in 23 cases (27.7%). The median time between
transplantation and 18F-FDG PET/CT was 735 (range,
448–829) days.