18F-FDG-PET/CT index for judging
non-destructive PTLD
ROC curve analysis was used to evaluate the value of each index in
diagnosing non-destructive PTLD. The results showed that
(SDL/LDL)*(SUVmaxBio/SUVmaxTon) had the largest AUC (0.923; 95% CI,
0.834–1.000) (Supplementary Figure 1 and Supplementary Table 1), and
the cut-off value was 0.264 (FIGURE 2 ) at the maximum value of
Youden’s index. According to the cut-off value, the patients were
divided into ≤ cut-off value group and > cut-off value
group, including 21 patients in the ≤ cut-off value group and 45
patients in the > cut-off value group. Lymph node biopsy
confirmed that 44 cases (66.7%) were true positive, 18 cases (27.3%)
were true negative, 1 case (1.5%) was false positive, and 3 cases
(4.5%) were false negative (TABLE 3 ). Using
(SDL/LDL)*(SUVmaxBio/SUVmaxTon) for the detection of non-destructive
PTLD, the sensitivity was 93.6%, the specificity was 94.7%, the PPV
was 97.8%, the NPV was 85.7%, and the accuracy was 93.9%
(TABLE 4 ).