18F-FDG-PET/CT index for judging non-destructive PTLD
ROC curve analysis was used to evaluate the value of each index in diagnosing non-destructive PTLD. The results showed that (SDL/LDL)*(SUVmaxBio/SUVmaxTon) had the largest AUC (0.923; 95% CI, 0.834–1.000) (Supplementary Figure 1 and Supplementary Table 1), and the cut-off value was 0.264 (FIGURE 2 ) at the maximum value of Youden’s index. According to the cut-off value, the patients were divided into ≤ cut-off value group and > cut-off value group, including 21 patients in the ≤ cut-off value group and 45 patients in the > cut-off value group. Lymph node biopsy confirmed that 44 cases (66.7%) were true positive, 18 cases (27.3%) were true negative, 1 case (1.5%) was false positive, and 3 cases (4.5%) were false negative (TABLE 3 ). Using (SDL/LDL)*(SUVmaxBio/SUVmaxTon) for the detection of non-destructive PTLD, the sensitivity was 93.6%, the specificity was 94.7%, the PPV was 97.8%, the NPV was 85.7%, and the accuracy was 93.9% (TABLE 4 ).