Patients’ basic information
From January 2014 to December 2021, 1431 children underwent pLT at the Department of Pediatric Transplantation, Tianjin First Central Hospital. A total of 76 patients were diagnosed with PTLD by lymph node biopsy, for an incidence rate of 5.31%. A total of 83 patients were <14 years old at the time of pLT and underwent lymph node biopsy and 18F-FDG PET/CT in the same period. According to the results of lymph node biopsy, 19 patients (22.9%) were PTLD-negative cases, 47 patients (56.7%) were diagnosed with non-destructive PTLD, 5 patients (6.0%) were diagnosed with polymorphic PTLD, 11 patients (13.3%) were diagnosed with monomorphic PTLD, and 1 patient (1.2%) was diagnosed with classical Hodgkin’s lymphoma PTLD (FIGURE 1 ). See TABLE 1 for the patient characteristics. There were 44 boys (53%) and 39 girls (47%), with a median age of 7.27 (range, 5.85–8.70) months. Among these patients, 73 (88%) underwent pLT for biliary atresia and 10 (12%) underwent pLT for other reasons. Sixty-four patients (77.1%) received LDLT and 19 patients (22.9%) received DDLT. The EBV result was positive in 60 cases (72.3%) and negative in 23 cases (27.7%). The median time between transplantation and 18F-FDG PET/CT was 735 (range, 448–829) days.