Abstract
Glycophagy is a novel selective autophagy characterized by glycogen
degradation via the lysosomal enzyme acid α-glucosidase (GAA).
Starch-binding domain-containing protein 1 (STBD1) is a glycogen cargo
receptor that mediates glycophagy through binding glycogen transport
into lysosomes. STBD1-dependent glycophagy has garnered considerable
interest in the pathology community, because its dysregulation causes
multiple diseases, with cancer being the most serious. Notably,
deletions and/or mutations in STBD1 promote tumorigenesis. In this
review, we first summarized the current understanding of STBD1,
including its structure, subcellular localization, tissue distribution,
and biological functions. Next, we examined the roles and molecular
mechanisms of STBD1-dependent glycophagy in various diseases (e.g.,
Pompe disease, Parkinson’s disease, cardiac diseases, and cancer). Based
on available research, we discussed the promising function and future of
STBD1, including its potential application as a therapeutic target in
glycogen-related diseases. We recommend using real-time diagnostic tools
to observe the progression of STBD1-mediated glycophagy and gain further
insight on the mechanism of action. Such details are needed to
investigate new avenues for glycogen-related disease therapy.