One of greatest common main cancerous tumor of the brain in adults is glioblastoma, which is fatal without treatment. For individuals diagnosed having glioblastoma, typical gold level treatment consists of surgical removal of the tumor supported by radiation treatment plus concurrent chemotherapy drugs. Despite this, overall, prognostic level is still dismal; approximately 12-to 15-month life expectancy is typical. Cell signaling, angiogenesis, Gene mutation have all been highlighted as promising areas to explore in the lookout for potential treatments, thanks to years of study. The pathophysiology of glioblastoma is now much more complicated due to new discoveries of extrachromosomal DNA (ecDNA). Numerous oncogenes found within those ecDNAs, which seem to be important driving therapeutic resistance, faster tumor progression and intra-tumoral heterogeneity, are also found in cancer cells nucleus, where their genome size is noticeably larger. Existing knowledge regarding therapy significance, tumor growth and ecDNA synthesis in glioblastoma will indeed be reviewed in this article.