Table 4: Frequency of adverse events in enrolled PWE on monotherapy and polytherapy
LAEP scale items LAEP scale items Monotherapy Monotherapy Polytherapy Polytherapy Statistical significance
N % N %
Unsteadiness Present 10 8.5 13 6.8 0.587
Absent 108 91.5 178 93.2
Tiredness Present 66 55.9 127 66.5 0.063
Absent 52 44.1 64 33.5
Restlessness Present 43 36.4 92 48.2 0.043*
Absent 75 63.6 99 51.8
Feelings of anger & aggression to others Present 105 88.9 182 95.3 0.036*
Absent 13 11.0 9 4.7
Nervousness or agitation Present 78 66.1 156 81.7 0.002**
Absent 40 33.9 35 18.3
Headache Present 56 47.5 113 59.2 0.045*
Absent 62 52.5 78 40.8
Hair loss Present 51 43.2 83 43.5 0.968
Absent 67 56.8 108 56.5
Problems with Skin (e.g. achne or rash) Present 7 5.9 14 7.3 0.635
Absent 111 94.1 177 92.7
Double or blurred vision Present 12 10.2 20 10.5 0.933
Absent 106 89.8 171 89.5
Upset stomach Present 19 16.1 26 13.6 0.547
Absent 99 83.9 165 86.4
Difficulty in concentrating Present 24 20.3 44 23.0 0.578
Absent 94 79.7 147 77.0
Trouble with mouth or gums Present 3 2.5 6 3.1 0.761
Absent 115 97.5 185 96.9
Shaky hands Present 22 18.6 65 34.0 0.003**
Absent 96 81.4 126 66.0
Weight gain Present 14 11.9 22 11.5 0.927
Absent 104 88.1 169 88.5
Dizziness Present 15 12.7 21 11.0 0.648
Absent 103 87.3 170 89.0
Sleepiness Present 31 73.7 63 67.0 0.213
Absent 87 26.3 128 33.0
Depression Present 35 29.7 98 51.3 0.000***
Absent 83 70.3 93 48.7
Memory problems Present 65 55.1 144 75.4 0.000***
Absent 53 44.9 47 24.6
Disturbed sleep Present 39 33.1 82 42.9 0.084
Absent 79 67.0 109 57.1
*p<0.05, **p<0.01, ***p<0.001 *p<0.05, **p<0.01, ***p<0.001 *p<0.05, **p<0.01, ***p<0.001 *p<0.05, **p<0.01, ***p<0.001 *p<0.05, **p<0.01, ***p<0.001 *p<0.05, **p<0.01, ***p<0.001 *p<0.05, **p<0.01, ***p<0.001