Table 3: Antiseizure medication ranges and significant differences in LAEP items between medications Table 3: Antiseizure medication ranges and significant differences in LAEP items between medications Table 3: Antiseizure medication ranges and significant differences in LAEP items between medications Table 3: Antiseizure medication ranges and significant differences in LAEP items between medications Table 3: Antiseizure medication ranges and significant differences in LAEP items between medications Table 3: Antiseizure medication ranges and significant differences in LAEP items between medications Table 3: Antiseizure medication ranges and significant differences in LAEP items between medications Table 3: Antiseizure medication ranges and significant differences in LAEP items between medications
Levetiracetam (LEV) Levetiracetam (LEV) Sodium Valproate (SV) Sodium Valproate (SV) Carbamazepine (CBZ) Carbamazepine (CBZ) Phenytoin (PHT) Phenytoin (PHT) Phenytoin (PHT)
Number of PWE 62 62 27 27 17 17 6 6 6
Dose range <1500mg ≥1500mg <1000mg ≥1000mg <800mg ≥800mg 100mg 100mg >100mg
N 28 34 18 9 14 3 3 3 3
LAEP item LAEP item LAEP item LAEP item LAEP item LAEP item LAEP item LAEP item LAEP item
Overall Score 25.18 28.03 26.11 25.11 28.79 23.00 25.00 25.00 32.33
Unsteadiness 1.04 1.09 1.17 1.11 1.07 1.00 1.00 1.00 1.33
Tiredness 1.61 1.91 1.61 1.22 1.79 1.00 1.00 1.00 2.33
Restlessness 1.39 1.59 1.28 1.11 1.43 1.33 1.00 1.00 1.67
Feelings of anger & aggression to others 2.25 2.62 2.44 2.33 2.79 2.33 2.67 2.67 3.00
Nervousness or agitation 1.68 1.97 1.83 1.89 2.07 1.67 1.33 1.33 2.00
Headache 1.50 1.62 1.50 1.33 1.57 1.00 2.00 2.00 1.33
Hair loss 1.71 1.59 1.39 1.33 1.79 1.00 1.33 1.33 1.33
Problems with Skin (e.g. achne or rash) 1.11 1.09 1.06 1.00 1.00 1.00 1.00 1.00 1.33
Double or blurred vision 1.14 1.06 1.17 1.00 1.21 1.00 1.00 1.00 1.00
Upset stomach 1.07 1.24 1.22 1.22 1.29 1.00 1.00 1.00 1.67
Difficulty in concentrating 1.04 1.38** 1.33 1.11 1.29 1.00 1.33 1.33 2.00
Trouble with mouth or gums 1.00 1.00 1.06 1.00 1.00 1.00 1.00 1.00 1.67
Shaky hands 1.14 1.29 1.22 1.22 1.57 1.00 1.00 1.00 1.33
Weight gain 1.11 1.09 1.11 1.11 1.14 1.33 1.00 1.00 1.33
Dizziness 1.04 1.21* 1.17 1.11 1.14 1.00 1.00 1.00 1.33
Sleepiness 1.21 1.41 1.17 1.44 1.50 1.33 1.00 1.00 2.00
Depression 1.21 1.76* 1.39 1.44 1.71 1.00 1.33 1.33 2.00
Memory problems 1.57 1.74 1.56 1.78 1.86 1.67 2.33 2.33 2.00
Disturbed sleep 1.36 1.41 1.44 1.33 1.50 1.33 1.67 1.67 1.67
Note: *p<0.05, **p<0.01 Note: *p<0.05, **p<0.01 Note: *p<0.05, **p<0.01 Note: *p<0.05, **p<0.01 Note: *p<0.05, **p<0.01 Note: *p<0.05, **p<0.01 Note: *p<0.05, **p<0.01 Note: *p<0.05, **p<0.01 Note: *p<0.05, **p<0.01 Note: *p<0.05, **p<0.01