Epilepsy is a common neurological disorder in which excessive and abnormal neuronal discharges can be observed and is characterized by recurrent seizures. The epileptogenesis is usually involved in neuropathological processes such as ion channel dysfunction, neuronal injury, inflammatory response, synaptic plasticity, glial cell proliferation and mossin fibrosis, currently the pathogenesis of epilepsy is not yet completely understood. A growing body of studies have shown that epigenetic regulation, such as histone modifications, DNA methylation, noncoding RNAs (ncRNAs), and restrictive element-1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) are also involved in epilepsy. However, the functional roles of epigenetics in pathogenesis and treatment of epilepsy are still to be explored. Therefore, in this review, we will summarize latest advances concerning the mechanisms of epigenetic regulation in epilepsy, which provide novel insight into therapy and biomarkers for epilepsy.