Methods
We retrospectively reviewed patient charts with a history of suspected
ADR, scored using both instruments and determined how each correlates
with laboratory and other investigations.
924 charts from the Clinical Pharmacology Clinic at the London Health
Sciences Centre were reviewed and 529 charts contained objective
findings to support or against the diagnosis of ADR. The participant age
ranged from 1 month old to 93 years.
We determined the sensitivity and specificity of Liverpool and Naranjo
tools for predicting ADRs with scores ranging from “Possible” to
“Definite” were considered positive and “Unlikely/Doubtful” as
negative for ADR. These results were confirmed by laboratory or clinical
(re-challenge) testing in 529 cases.