Study Population
In the trial ,58 patients with more than 10,000 PVCs during 24-hour ambulatory rhythm Holter monitoring were compared to 53 healthy persons who served as the control group. Participants were excluded if they had a left ventricular ejection fraction (LVEF) of less than 50 percent, LV hypertrophy, more than mild valvular heart disease, coronary artery disease, significant congenital heart disease, other arrhythmias (such as atrial flutter, atrial fibrillation, supraventricular tachycardia), uncontrolled or more than grade 1 arterial hypertension, dyslipidemia, obstructive sleep apnea, or a history of smoking. The local ethics committee approved of the research. All participants who participated in the study provided their informed permission.