Infliximab (INF) is a biological widely used in the treatment of various auto-immune diseases including Behçet’s disease. INF and other pro-inflammatory cytokines, has been retained in some cases as a factor in the pathogenesis of various neuropsychiatric conditions. Herein we present the case of an adult man with Behçet’s disease (BD) who developed acute depression leading to suicide after the fourth infusion of infliximab. The patient did not experience disabling depressive syndrome, or suicidal thoughts before. He has never made a prior suicide attempt. He denied any previous episodes of mania or psychosis or a history of trauma. Our patient received a serotonin reuptake inhibitor with a good response which allowed us to maintain infliximab therapy.