5. Conclusions

In this review, we comprehensively summarize the published PopPK models of posaconazole. At regular doses, tablets and intravenous formulations have higher exposure than oral suspensions. Nevertheless, the PK of posaconazole were influenced by various factors such as the incidence of diarrhea, body weight, and concomitant medications. Routine TDM of posaconazole is necessary to ensure drug efficacy and reduce bacterial resistance. More relevant studies are needed to explore the effect of covariates on posaconazole PK and to conduct external validation to examine the extrapolation of the models.