5. Conclusions
In this review, we comprehensively summarize the published PopPK models
of posaconazole. At regular doses, tablets and intravenous formulations
have higher exposure than oral suspensions. Nevertheless, the PK of
posaconazole were influenced by various factors such as the incidence of
diarrhea, body weight, and concomitant medications. Routine TDM of
posaconazole is necessary to ensure drug efficacy and reduce bacterial
resistance. More relevant studies are needed to explore the effect of
covariates on posaconazole PK and to conduct external validation to
examine the extrapolation of the models.