ACKNOWLEDGMENTS
This study was supported by the Natural Science Foundation of China (81970534), Natural Science Foundation of Anhui Province (2008085MH273), Anhui Fund for Distinguished Young Scholars (2022AH020050), the University Synergy Innovation Program of Anhui Province (GXXT-2020-025, GXXT-2020 -063), the Scientific Research Promotion Fund of Anhui Medical University (2022xkjT010) and Scientific Research Platform Improvement Project of Anhui Medical University (2022xkjT045), Anhui Provincial Universities postgraduate Science Foundation (YJS20210294) and Research Fund of Anhui Institute of translational medicine (2021zhyx-B06,2022zhyx-B07).