FIGURE 9. PSTPIP2 regulates caspase-8 and inhibits kidney injury
by suppressing PANoptosis.
(A) Protein level of caspase-8 in WT, AAI-treated WT mice, untreated
PSTPIP2-KI, and AAI-treated PSTPIP2-KI mice analyses using western blot.
(B) The protein level of caspase-8 in mTECs treated with pEX-2-PSTPIP2
analyses using western blot. (C) Photomicrographs of immunohistochemical
of Caspase-8 in WT, AAI-treated WT mice, untreated PSTPIP2-KI, and
AAI-treated PSTPIP2-KI mice (Scale bar = 40 μm). (D) Immunofluorescence
staining of caspase-8 in mTECs treated with pEX-2-PSTPIP2 (Scale bar =
100 μm). Data are presented as the mean ± SEM, n = 5. ns, not
significant; *P < 0.05, significantly different, as indicated.