2.3 | Histone Deacetylase Inhibitors Mouse Model
Briefly, Six- to eight-week-old male C57BL/6 mice were randomly divided into four groups (n = 5 per group): the vehicle group mice were administered isotonic sodium chloride solution in a single i.p. injection. The AAI group mice were administered AAI at 10 mg/kg in a single i.p. injection. The AAI+FK-228 group mice were treated with FK-228 (2 mg/kg body weight) via gavage. The FK-228 group mice were treated with FK-228 alone (2 mg/kg body weight) via gavage. The last two groups were treated every 24 h for two days after administering AAI at 10 mg/kg in a single i.p. injection.