FIGURE 10. Caspase-8 level increases in AAV9-mediated PSTPIP2 inhibition mice.
(A) Protein level of caspase-8 using western blot. (B) The protein level of caspase-8 in mTECs treated with siRNA-PSTPIP2 and FK-228 analyses by western blot. (C) Photomicrographs of immunohistochemical of caspase-8 in WT, AAI-treated WT mice, AAI-treated PSTPIP2-KI mice, and AAI-treated PSTPIP2-KI mice with AAV9 (Scale bar = 40 μm). (D) Immunofluorescence staining of caspase-8 in mTECs treated with siRNA-PSTPIP2 and FK-228 (Scale bar = 100 μm). Data are presented as the mean ± SEM, n = 5. ns, not significant; *P < 0.05, significantly different, as indicated.