FIGURE 9. PSTPIP2 regulates caspase-8 and inhibits kidney injury by suppressing PANoptosis.
(A) Protein level of caspase-8 in WT, AAI-treated WT mice, untreated PSTPIP2-KI, and AAI-treated PSTPIP2-KI mice analyses using western blot. (B) The protein level of caspase-8 in mTECs treated with pEX-2-PSTPIP2 analyses using western blot. (C) Photomicrographs of immunohistochemical of Caspase-8 in WT, AAI-treated WT mice, untreated PSTPIP2-KI, and AAI-treated PSTPIP2-KI mice (Scale bar = 40 μm). (D) Immunofluorescence staining of caspase-8 in mTECs treated with pEX-2-PSTPIP2 (Scale bar = 100 μm). Data are presented as the mean ± SEM, n = 5. ns, not significant; *P < 0.05, significantly different, as indicated.