Clinical Case n° 2
A 35-year- old male with a generalized vitiligo involving the face, the
upper limbs, associated to a thyroid insufficiency and a pernicious
anemia was recruited. A gastroscopy was proposed to the patient
following the recent discovery of his pernicious anemia and the positive
detection of anti parietal cells antibodies . Helicobacter Pylori
research was negative. A biopsy was performed at the edge of a vitiligo
lesion including depigmented and normally pigmented areas. Skin and
gastric samples were stained with HES and immunostained with anti E-
Cadherin for assessment of an adhesivity defect, anti Collagen IV for
detecting an impairment of basement membrane and CD8 antibodies for
evaluating the inflammatory infiltrate. Histological
description :infiltration of plasma cells and lymphocytes involving the
full thickness of lamina propria with atrophic glandular alteration and
in some places » pseudopyloric metaplasia (5)