Graphical Abstract
Abbreviations
CNS: central nervous system
DAMGO: [D‐Ala2,N‐Me‐Phe4,Gly5‐ol]‐enkephalin
GPCR: G-protein coupled receptor
HEK MOR-WT: HEK293 cells stably transfected with mu opioid receptor wild
type
MOR: mu opioid receptor
NFEPP: (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide
NLX: naloxone
pKa: acid dissociation constant
PNS: peripheral nervous system
PTX: pertussis toxin
VDCC: voltage dependent calcium channel
M. Özgür Celik ORCID ID: 0000-0002-7706-4964
Viola Seitz ORCID ID: 0000-0002-8086-8090
Fatih Yergöz ORCID ID: 0000-0002-9709-8563
Sandeep Dembla ORCID ID: 0000-0003-2708-4390
Stefan Schulz ORCID ID: 0000-0002-5997-8885
Christoph Stein ORCID ID: 0000-0001-5240-6836