Figure 4:
Modeled structures of full length TGFBI and its variants are depicted in cartoon representation. The residue substitution at 323 position is magnified along with the C-terminal helices in wild type and 649 frameshift TGFBI .
Figure 5 :
Porcupine plots showing correlated movements of the protein throughout the 200ns simulations along PC1. The mutant forms of TGFB I were more dynamic compared to the wild type TGFBI.