Figure 6:
Free Energy Landscape (FEL) generated from the projection of trajectory on PC1 and PC2. The FEL for wild type TGFBI was deeper compared to the shallow FELs of the mutant forms due to decreased stability of the protein.
Supplementary Figure 1: (A) RMSD plots showing structural deviation of the wild type and mutant TGFBI proteins(B) Radius of gyration plots showing compactness of the protein. (C) RMSF plot showing residue fluctuation throughout the 200ns simulations
Table 1: Ocular features of the 3 girls( with Pedigree notation) with GAPO Syndrome