Figure 6:
Free Energy Landscape (FEL) generated from the projection of trajectory
on PC1 and PC2. The FEL for wild type TGFBI was deeper compared
to the shallow FELs of the mutant forms due to decreased stability of
the protein.
Supplementary Figure 1: (A) RMSD plots showing
structural deviation of the wild type and mutant TGFBI proteins(B) Radius of gyration plots showing compactness of the
protein. (C) RMSF plot showing residue fluctuation throughout
the 200ns simulations
Table 1: Ocular features of the 3 girls( with Pedigree notation) with
GAPO Syndrome