PK analysis of antimicrobial agents
The PK profiles of nacubactam and aztreonam in neutropenic mice are
shown in Fig. 3. The plasma concentration curve for nacubactam and
aztreonam best fitted the two-compartment model. The PK parameters of
each drug analysed from the plasma concentration curve are listed in
Table S2. C max and AUC of each drug showed good
linearity within the dose range tested (Fig. S2). The plasma protein
binding rates of nacubactam and aztreonam were similar among the three
concentrations (Table S3), with averages of 3.87% and 57.1% for
nacubactam and aztreonam, respectively. The average values were used for
PK/PD analysis.