PK analysis of antimicrobial agents
The PK profiles of nacubactam and aztreonam in neutropenic mice are shown in Fig. 3. The plasma concentration curve for nacubactam and aztreonam best fitted the two-compartment model. The PK parameters of each drug analysed from the plasma concentration curve are listed in Table S2. C max and AUC of each drug showed good linearity within the dose range tested (Fig. S2). The plasma protein binding rates of nacubactam and aztreonam were similar among the three concentrations (Table S3), with averages of 3.87% and 57.1% for nacubactam and aztreonam, respectively. The average values were used for PK/PD analysis.