Simulation in clinical dosing
Using PK data of nacubactam (Mallalieu et al., 2020) and aztreonam
(Scully et al., 1983),(Kita et al., 1986) in healthy subjects,
%f T>MICi and
%f T>CT against strains used in this
study were calculated in the case that aztreonam (0.5 g, 1 g, 2 g) and
nacubactam (0.05 g, 0.15 g, 0.5 g, 1 g, 2 g) were co-administered every
8 hrs. In the simulation case of
%f T>CT, aztreonam 1,200, 2,400, and
4,800 mg kg-1 day-1 in mice were
calculated as aztreonam 0.5 g q8h, 1 g q8h, and 2 g q8h in human,
respectively, because of similar kinetic transition.