PK/PD analysis with fT>CT
The percentage of time that the free plasma nacubactam concentration at each dose exceeded the CT value (0.125, 0.25, 0.5, 1, 2, and 2.5 mg L-1) was calculated as %f T>CT. The mean change in the bacterial count of each group obtained by in vivo PD study was plotted based on % f T>CT and analysed by the Inhibitory Effect Sigmoid I maxModel [equation (2)].