PK/PD analysis with fT>CT
The values of f T>CT in each dose
group calculated from the PK data were plotted against the change in
bacterial counts obtained in the PD study. TheR 2 value in each CT of
nacubactam was analysed using the Inhibitory Effect SigmoidI max Model (Fig. S3-5). Fig. 7 summarised the
relationship between CT of nacubactam andR 2 values. The CT values with
the highest R 2 value for K. pneumoniaeATCC BAA-2473 when combined with aztreonam 1,200, 2,400 and 4,800 mg
kg-1 day-1 were 2, 1 and 0.125 mg
L-1, respectively (Fig. 7A). For K. pneumoniaeMSC 21664, the CT value with the highestR 2 values was 0.125 mg L-1for all doses (Fig. 7B). For K. pneumoniae MSC 21444,
CT = 0.25 mg L-1 with aztreonam 1,200
mg kg-1 day-1 and CT= 0.125 mg L-1 with 2,400 and 4,800 mg
kg-1 day-1 had the highestR 2 values (Fig. 7C).