PK/PD analysis with fT>CT
The percentage of time that the free plasma nacubactam concentration at
each dose exceeded the CT value (0.125, 0.25, 0.5, 1, 2,
and 2.5 mg L-1) was calculated as
%f T>CT. The mean change in the
bacterial count of each group obtained by in vivo PD study was
plotted based on % f T>CT and
analysed by the Inhibitory Effect Sigmoid I maxModel [equation (2)].