Because of the involvement of three main organs (brain, skin, and gastrointestinal organs), the diagnosis of Multisystem inflammatory syndrome in children (MIS-C) was suspected. brain MRI and retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) analysis were reported with the signs of papilledema and flattening of the posterior globe (Figure 1 and 2), and the sonography of kidneys showed marked parenchymal thinning and cortical damage. The echography showed minimal pericardial effusion and trivial tricuspid and pulmonary valve regurgitation. Lumbar Puncture (LP) was performed on the patient. The result showed opening pressure of 40 cmH2O. The pressure of CSF was 30 cmH2O. Protein of 28, sugar of 65, and 0 cell count were also observed.